Development and Evaluation of Microballons Based Extended Release Drug Delivery System for Hypertension Therapy

Ganesh S Bangale, Shinde Gv and Rajesh Ks
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Ganesh S Bangale: Government College of Pharmacy, Amravati (M.S.), India
Shinde Gv: Mill Laboratories Pvt Ltd, Gujarat, India
Rajesh Ks: Zydus Healthcare Ltd, India

Global Journal of Pharmacy & Pharmaceutical Sciences, 2019, vol. 7, issue 4, 117-127

Abstract: The objective of the present work was to formulate and evaluate micro balloons of Captopril to for prolongation of gastric residence time. The micro balloons were prepared by the solvent diffusion technique using different ratio of Ethyl cellulose, HPMCK4M & acrylic polymers as Eudragit RL100. Micro balloons characterized for micrometrics properties found in passable to good range, the yield of micro balloons was up to 71.20 ±4.68 to 92.25 ±2.34 % and % entrapment efficiency was found to be 71.40±1.64 to 87.34±2.54% respectively. The size of micro balloons formulations was in the range of 159.1±4.09 to 203.42±5.61. The shape and surface morphology of prepared micro balloons were characterized by scanning electron microscopy.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:7:y:2019:i:4:p:117-127

DOI: 10.19080/GJPPS.2019.07.555718

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