Increased Vitamin D Signalling Markers in the Skin of Atopic Dermatitis Patients

Christin Weise, Margitta Worm and Ralph Rühl
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Christin Weise: Department of Dermatology and Allergology, Allergy-Center-Charité, Charité-Universitätsmedizin, Germany
Margitta Worm: NBS Scientific GmbH, Weinheim, Germany
Ralph Rühl: Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary

JOJ Dermatology & Cosmetics, 2020, vol. 3, issue 4, 76-78

Abstract: Vitamin D-mediated signalling is discussed controversial in regard of allergic sensitization and atopic dermatitis (AD). In this study we determined that in AD patients two main target genes of vitamin D-mediated signalling CYP24A1 (vitamin D 24-hydroxylase) and TSLP (thymic stromal lymphopoietin) are strongly upregulated in both affected as well as non-affected skin of AD patients vs healthy volunteers skin. We conclude that this increased local vitamin D-mediated signalling resulting is in a strong local pro-inflammatory and pro-allergic conditions present in the skin of AD patients with an impact on the systemic vitamin D-signalling and systemic allergic sensitization.

Keywords: Open Access Journal of Dermatology & Cosmetics; juniper publishers dermatology Journals; dermatology journal impact factor ranking; dermatology online journal impact factor; dermatology online journal psoriasis; dermatology online journal author; scholarly open access journals; peer reivewed journals; junipe publishers review (search for similar items in EconPapers)
Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jjojdc:v:3:y:2020:i:4:p:76-78

DOI: 10.19080/JOJDC.2020.03.555618

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