Do Normal Human Epidermal Keratinocytes Require a Priming Step to Activate the NLRP3 Inflammasomes to Exogenous Threats

James V Gruber
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James V Gruber: JVG Innovative Consulting, Washington, USA

JOJ Dermatology & Cosmetics, 2021, vol. 3, issue 5, 89-90

Abstract: In recent work examining the expression of inflammasome-induced release of active Caspase-1 on Normal Human Epidermal Keratinocytes (NHEK), it was noted that two exogenous threats, UVB radiation and ATP were effective at activating the NLRP inflammasomes and inducing the release of significant quantities of active Caspase-1 [1]. It is generally thought that activation of the NLRP inflammasomes is a two-step process requiring: 1) activation of the NLRP inflammasome by signaling from the Toll-Like Receptors (TLR), and 2) creation of the inflammasome proteins after transcription via NF-ƙβ nuclear signaling, assembly of the inflammasome complex and subsequent activation of Caspase-1 upon binding to the ASC binding domain of the inflammasome [2].

Keywords: Open Access Journal of Dermatology & Cosmetics; juniper publishers dermatology Journals; dermatology journal impact factor ranking; dermatology online journal impact factor; dermatology online journal psoriasis; dermatology online journal author; scholarly open access journals; peer reivewed journals; junipe publishers review (search for similar items in EconPapers)
Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jjojdc:v:3:y:2021:i:5:p:89-90

DOI: 10.19080/JOJDC.2021.03.555621

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