Nanoemulgel for Transdermal Delivery of Cyclobenzaprine Hydrochloride: Design, Characterization and In-Vitro Studies

Lakshmana Prabu S, Sharvanan Sp, Aravindan S, Bhuvaneswari A and Manikandan V
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Manikandan V: Department of Pharmaceutical Technology, Anna University, India

Novel Approaches in Drug Designing & Development, 2017, vol. 1, issue 5, 87-92

Abstract: Recently utilizing nanoemulsion as a vehicle for deliver the drug through transdermal drug delivery has been increased. The purpose of the present study was to develop a nanoemulsion formulation of cyclobenzaprine hydrochloride and characterize for transdermal drug delivery. Aqueous titration method was adopted for various oil-in-water nanoemulsion preparations. The prepared nanoemulsions were characterized for its particle size, polydispersity index, zeta potential, TEM, pH, viscosity, drug content, spread ability and its in-vitro release studies. Drug excipient compatibility study results reveals that the excipient used in the nanoemulsion is having compatibility. Based on its in-vitro release studies formulation F14 showed higher release compared to other formulations. Formulation F14 was converted into Nanoemul gel and characterized. The in-vitro release profile of the optimized formulation was compared with the nanoemul gel. In conclusion, the results of the present investigation suggested that the developed nanoemul gel formulation of cyclobenzaprine hydrochloride can be used as a vehicle for enhancement of bioavailability through transdermal drug delivery

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Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jnapdd:v:1:y:2017:i:5:p:87-92

DOI: 10.19080/NAPDD.2017.01.555575

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