Formulation of Prunus Amygdalus (Family: Rosaceae) Gum Based Compression Coated Tablet for Colon Targeted Delivery of 5-Aminosalicylic Acid

Koushal Dhamija, Vandana Arora, Kulkarni Gt and Vandana
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Vandana Arora: Department of Pharmacy, Lloyd Institute of Management and Technology, India
Kulkarni Gt: Amity Institute of Pharmacy, Amity University, India
Vandana: Rameesh Institute of Vocational and Technical Education, India

Novel Approaches in Drug Designing & Development, 2017, vol. 2, issue 5, 67-70

Abstract: This research deals with formulation of compression coated tablet of 5-Aminosalicylic acid and further evaluated for colon targeting ability. Drug 5-aminosalicylic acid is degraded in stomach in the presence of gastric pH so colon targeting is best way to achieve therapeutic effect. Initially core tablet of drug was prepared using microcrystalline cellulose as diluents and further it was compression coated using various concentration of Prunus amygdalus gum. Prepared tablets were evaluated for various physical and mechanical parameters such as hardness, size and shape, friability and weight variation. To evaluate drug release ability of formulated tablet in to colon, In vitro drug release study was carried out in 0.1 N HCl and phosphate buffer pH 7.4. Formulated tablets were found to be round in shape with 13.436±0.020 to 13.482±0.017mm diameter. Hardness of tablets was found to be 18.22±0.12 to 18.56±0.04. Friability of prepared tablets were within Pharmacopoeial limit (i.e.

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Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jnapdd:v:2:y:2017:i:5:p:67-70

DOI: 10.19080/NAPDD.2017.02.555591

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