Phenolic Antioxidants as Drugs for Alzheimer’s Disease: Oxidative Stress and Selectivity

Peter Kovacic
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Peter Kovacic: Department of Chemistry and Biochemistry, San Diego State University, USA

Novel Approaches in Drug Designing & Development, 2017, vol. 2, issue 5, 95-97

Abstract: Oxidative stress (OS) is a well-recognized feature of Alzheimer’s disease. However, evenup to the present time, there is controversy and conflicting results concerning the role of antioxidants (AO). This review provides evidence for the beneficial influence of phenols and phenolic ethers as AOs. Other mechanisms were advanced for these drugs previously; however, this report adds validity to the positive influence of AOs on Alzheimer’s disease. An important aspect to be recognized is the variability of action with a class based on competing pathways. The AOs involved are the following: curcumin, sesamol, rivastigmine, galantamine, donepezil, and piperine.

Keywords: juniper publishers; drug designing pdf; drug designing articles; drug designing abstract; drug designing journal; modern approaches in drug designing journal; drug designing & intellectual properties international journal; peer reviewed open access journals; high impact journals; juniper publishers review (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jnapdd:v:2:y:2017:i:5:p:95-97

DOI: 10.19080/NAPDD.2017.02.555598

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