Inhibition of HIV-1 Transcription Through Disruption of TAT-PP1 Interaction as a Novel Target for Functional HIV Cure

Marina Jerebtsova and Sergei Nekhai
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Marina Jerebtsova: Department of Microbiology, College of Medicine, Howard University, USA
Sergei Nekhai: Department of Medicine, College of Medicine, Howard University, USA

Novel Approaches in Drug Designing & Development, 2019, vol. 4, issue 4, 95-97

Abstract: Although combination antiretroviral therapies (cART) effectively suppress HIV-1 replication, viral rebound occurs shortly after therapy cessation. The major barrier to HIV-1 cure is a pool of latently infected CD4+ T cells, called the latent reservoir. Activation of viral transcription from integrated provirus is a key point for both viral latency and active HIV-1 replication. Here we discuss novel small-molecule inhibitors of HIV-Tat interaction with host protein phosphatase 1 as potential block and lock strategy for functional HIV cure.

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Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jnapdd:v:4:y:2019:i:4:p:95-97

DOI: 10.19080/NAPDD.2019.04.555642

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