Supramolecular Synthons as Related to Cooperativity in Biocomplexes: towards Design and Development of Oligopeptide-Based Modern Drugs and Cosmeceuticals

Joanna Bojarska, Wojciech M. Wolf, Krzysztof Kaczmarek and Janusz Zabrocki
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Wojciech M. Wolf: Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromski St. 116, 90-924 todz, Poland
Janusz Zabrocki: Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromski St. 116, 90-924 todz

Novel Approaches in Drug Designing & Development, 2019, vol. 5, issue 2, 23-25

Abstract: Short oligopeptides of natural and synthetic origin are becoming increasingly important not only in research and modern drugs development but also as cosmeceuticals. On the other hand, complexes of proteins with peptide ligands have attracted wide attention in biomedicine. In particular, in silico and in vivo drug development is concerned. Therefore, detailed knowledge on supramolecular and energetic aspects of protein-peptide weak non-covalent interactions and their systematic evaluation is essential. In this mini review, we shed light into increasing potential of supramolecular synthon approach when cooperative effects in stabilization of biomolecules are to be concerned. We put forward the views on interpretation of protein–peptide ligand binding modes and the future development of innovative APIs.

Keywords: juniper publishers; drug designing pdf; drug designing articles; drug designing abstract; drug designing journal; modern approaches in drug designing journal; drug designing & intellectual properties international journal; peer reviewed open access journals; high impact journals; juniper publishers review (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jnapdd:v:5:y:2019:i:2:p:23-25

DOI: 10.19080/NAPDD.2019.05.555656

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