Nutritional Regulation of Growth Hormone/ Insulin-like Growth Factor-1 Axis

Bo Ban and Qianqian Zhao
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Bo Ban: Department of Endocrine and Metabolic diseases, Hospital of Jining Medical University, China
Qianqian Zhao: Jining Medical University, China

Nutrition & Food Science International Journal, 2018, vol. 7, issue 5, 154-156

Abstract: The growth hormone (GH)/insulin-like growth factor-1 (IGF-1), a central growth-regulatory system in human, can be affected by multiple factors, of which nutrition is an important regulatory factor. Low GH/IGF-1 status is usually regarded as a functional condition of nutritional disorder, and it could be largely reversible after a nutritional supplement. The GH/IGF-1 axis consists of a series of finely regulated molecular mechanisms that are susceptible to protein calorie deficiency. In addition, malnutrition could induce the nutritionally responsive proteins that block hepatic GH signal transduction by inhibiting the JAK/STAT pathway, thereby limiting the generation of IGF-1. Taken together, nutrition is an important regulator of for human growth and development. However, to date, the association between nutrition and GH/IGF-1 axis remains incompletely understood. The present paper aims at reviewing existing literatures on the probable effects of nutrition on the GH/IGF-1 axis.

Keywords: juniper publishers; nutrition journal; nutrition journal articles; nutrition journal impact factor; nutrition impact factor; nutrition journal articles; nutrition research journal; nutrition research articles; Food Science International Journal; Nutrition & Food Science; juniper publishers; juniper publishers journals (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jnfsij:v:7:y:2018:i:5:p:154-156

DOI: 10.19081/NFSIJ.2018.07.555725

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