Supernumerary Philadelphia Positive Hyperdiploid Acute Lymphoblastic Leukemia: A Bad or A Good Prognosis? Single Case and Review of Literature

Nivedita Pathak and Akhilesh Mishra
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Nivedita Pathak: Department of Pediatrics, All India Institute of Medical Sciences, India
Akhilesh Mishra: Department of Radiation Oncology, VMMC & Safdarjung Hospital, India

Open Access Blood Research & Transfusion Journal, 2017, vol. 1, issue 4, 66-68

Abstract: Prognosis of ALL patients with Ph chromosome is known to be poor and that of hyper diploid karyotype is found to be good. Hyper diploid karyotype with supernumerary Philadelphia chromosome is a rarer entity. We are reporting a case of supernumerary Philadelphia chromosome positive, hyper diploid acute lymphoblastic leukemia and reviewing literature to find out the discrepancies in defining prognosis of such cases. Outcome heterogeneity changes according to chromosomal gain/loss in general so the challenge still remains. Such uncommon and atypical presentations have always been enigmatic as far as the correct approach to their clinical management is concerned. Should we need to move towards more individualized approach for better outcomes?

Keywords: Open Access Blood Research Journal; Open Access Blood Research & Transfusion Journal; juniper publishers; Open Access; Blood Research & Transfusion Journal; blood research impact factor; blood research topics; blood research paper; blood research & transfusion journa (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:joabtj:v:1:y:2017:i:4:p:66-68

DOI: 10.19080/OABTJ.2017.01.555566

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