Correlation of Acute Chest Syndrome with e-NOS, ARG1 and GSNOR Gene Polymorphisms in Omani Sickle Cell Patients

Aiman Al Wahaibi, Anil Pathare, Shoaib Al Zadjali and Salam Alkindi
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Aiman Al Wahaibi: Department of Medicine, Oman Medical Specialty Board, Oman
Anil Pathare: Department of Haematology, Sultan Qaboos University Hospital, Oman
Shoaib Al Zadjali: College of Medicine and Health Sciences, Oman
Salam Alkindi: Department of Haematology, Sultan Qaboos University Hospital, Oman

Open Access Blood Research & Transfusion Journal, 2018, vol. 1, issue 5, 100-102

Abstract: Acute chest syndrome (ACS), is the most common pulmonary complication of sickle cell disease (SCD) and reduced nitric oxide (NO) is considered to play a significant role. NO induces vasodilatation and helps in the recruitment of neutrophils. However, the endothelial nitric oxide synthase (NOS3) gene polymorphisms T-786C significantly reduces eNOS gene promoter activity, whereas the E298D changes an amino acid in the enzyme’s oxygenase domain. The expression of eNOS is also related to the number of 27bp repeat VNTRs in intron 4, with genotype 4bb showing a decrease in eNOS expression whereas, homozygosity for the minor allele of GSNOR SNP rs28730619 is associated with increased risk of asthma. such as bleeding or thrombosis.

Keywords: Open Access Blood Research Journal; Open Access Blood Research & Transfusion Journal; juniper publishers; Open Access; Blood Research & Transfusion Journal; blood research impact factor; blood research topics; blood research paper; blood research & transfusion journa (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:joabtj:v:1:y:2018:i:5:p:100-102

DOI: 10.19080/OABTJ.2018.01.555573

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