Implications of HLA in Transfusion Related Immune Complications Like TRALI and Platelet Refractoriness

Meenakshi Singh, Selma D’Silva and Anisha Navkudkar
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Anisha Navkudkar: HLA and Immunogenetics Laboratory, Department of Transfusion Medicine, Tata Memorial Hospital, India

Open Access Blood Research & Transfusion Journal, 2018, vol. 1, issue 5, 103-105

Abstract: Transfusion-related acute lung injury (TRALI) is defined as a new acute lung injury (ALI) that develops during or within 6 hours of transfusion and is a leading cause of transfusion-related morbidity and mortality [1]. The causative antibodies in TRALI may be directed against class I or II human leukocyte antigens (HLA) or human neutrophil antigens (HNA). It may also be caused by lipid products from the cellular breakdown, which accumulates in stored blood products and prime, activate neutrophils. TRALI can occur in patients undergoing repeated platelet transfusions and has mortality rates between 6-20%. Thus, it is important to identify these cases and address the issues related to the patients and implicated donors. such as bleeding or thrombosis.

Keywords: Open Access Blood Research Journal; Open Access Blood Research & Transfusion Journal; juniper publishers; Open Access; Blood Research & Transfusion Journal; blood research impact factor; blood research topics; blood research paper; blood research & transfusion journa (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:joabtj:v:1:y:2018:i:5:p:103-105

DOI: 10.19080/OABTJ.2018.01.555574

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