Successful Treatment of Disseminated Fungal Infections in three Pediatric Patients with Acute Lymphoblastic Leukemia

Funda Tekkeşin1, Zühre Kaya, Ülker Koçak, İdil Yenicesu, EmineBetül Derinkuyu, Alp Özgün Börcek, BurcuCeylanCura Yayla, Hasan Tezer, Ayşe Kalkanci and Alper Ceylan
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Ä°dil Yenicesu: Department of Pediatric Hematology, Gazi University, Turkey
EmineBetül Derinkuyu: Department of Pediatric Radiology, Gazi University, Turkey
Alp Özgün Börcek: Department of Neurosurgery, Gazi University, Turkey
Hasan Tezer: Department of Pediatric Infectious Diseases, Gazi University, Turkey
AyÅŸe Kalkanci: Department of Microbiology, Gazi University, Turkey
Alper Ceylan: Department of Otorhinolaryngology, Gazi University, Turkey

Open Access Blood Research & Transfusion Journal, 2018, vol. 2, issue 1, 1-4

Abstract: We present the cases of three children with acute lymphoblastic leukemia (ALL) who developed disseminated invasive fungal infections (IFIs) (Aspergillus spp. n=1, Candida spp. n=2). All were successfully treated with antifungal drugs and ancillary treatments; however, in two cases, leukemic cells were not eradicated by chemotherapy before transplantation. It has been noted that, despite the success of novel antifungal drugs in patients with ALL, long-lasting IFIs during chemotherapy may negatively affect leukemia prognosis. We emphasize the need for guidelines to provide assistance in preventing, evaluating and treating IFIs in this patient group.

Keywords: Open Access Blood Research Journal; Open Access Blood Research & Transfusion Journal; juniper publishers; Open Access; Blood Research & Transfusion Journal; blood research impact factor; blood research topics; blood research paper; blood research & transfusion journa (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:joabtj:v:2:y:2018:i:1:p:1-4

DOI: 10.19080/OABTJ.2018.02.555576

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