Neurological Manifestations of Cobalamin Deficiency

Ammouri, Harmouche H, Khibri, Maamar M, Mezalek Tazi Z, Adnaoui M, Benkirane S, Azlarab M and Mouatassim N
Additional contact information
Adnaoui M: Department of Internal medicine, University Mohamed V of medicine, Morocco
Azlarab M: Laboratoire central d’hématologie, University Mohamed V of medicine, Morocco
Mouatassim N: Department of Radiology, University Mohamed V of medicine, Morocco

Open Access Journal of Neurology & Neurosurgery, 2019, vol. 12, issue 2, 50-58

Abstract: Vitamin B12 (cobalamin) is synthesized by microorganisms and detected in trace amounts mostly in foods of animal origin. The absorption and transporting mechanisms depended on three key proteins: haptocorrin, intrinsic factor and transcobalamin. On the peripherу cobalamin circulates only in binding with proteins transcobalamin I and II (holotranscobalamin). Holotranscobalamin is absorbed by different cells, whereas transcobalamin I-binded vitamin B12 - only by liver and kidneys. Two forms of cobalamin were identified as coenzymes of cellular reactions which are methylcobalamin and hydroxyadenosylcobalamin. The interaction between folate and B12 is responsible for the megaloblastic anemia seen in both vitamin deficiencies. Vitamin B 12 is necessary for the development and initial myelination of the central nervous system as well as for the maintenance of its normal function.

Keywords: Open Access Journal of Neurology; Journal of Neurology & Neurosurgery; Open Access Journal; juniper publishers; neurology open access journals; journal of neurology; neurology indexed journals; neurology scholarly journals; journal of neurology; neurology journals impact factor; juniper publishers reivew (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/oajnn/pdf/OAJNN.MS.ID.555834.pdf (application/pdf)
https://juniperpublishers.com/oajnn/OAJNN.MS.ID.555834.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:joajnn:v:12:y:2019:i:2:p:50-58

DOI: 10.19080/OAJNN.2019.12.555834

Access Statistics for this article

Open Access Journal of Neurology & Neurosurgery is currently edited by Sophia Mathis

More articles in Open Access Journal of Neurology & Neurosurgery from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().