Differential Expression of Kinases and Cell Cycle Proteins in EW

Scinto Lfm and Changiz Geula
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Scinto Lfm: Cambridge Neuro diagnostics LTD, UK
Changiz Geula: Northwestern University Medical School, USA

Open Access Journal of Neurology & Neurosurgery, 2017, vol. 2, issue 5, 92-100

Abstract: The Edinger-Westphal (EW) of the nucleus of cranial nerve III (NCNIII), in contrast to the somatic portion, is an early site of pathology and cell loss in Alzheimer’s disease (AD) and the aging brain. Cell loss in the EW accounts for the observed pupillary hypersensitivity in Alzheimer’s disease (AD) patients to challenge with dilute tropicamide that could potentially serve as a biomarker for AD. The remarkable specificity of pathophysiology and cell loss offers a possible heuristic model by which to study selective cell vulnerability. Neurochemical differences in the somatic and EW portions of the NCNIII may account for their differential vulnerability. The EW pathology consists of phosphorylated tau in oligomers, tangles and neurites. This suggests that neurochemicals shown to be critical to the metabolism and phosphorylation of tau may be differentially expressed at the protein level in these two cell groups. This study examined the cellular expression of Cdc2, Cdk5 kinases, the prolyl isomerase Pin 1 and mitotic phosphoepitopes visualized by MPM-2 using immunohistochemical methods. The results demonstrated that the expression of target neurochemicals differs in the EW as opposed to somatic cell groups and in AD patients versus controls. The variability in the expression of some of these proteins may account for the observed regionally specific pathophysiology and cell loss within the NCNIII and perhaps also other cell groups vulnerable in AD and ageing.

Keywords: Open Access Journal of Neurology; Journal of Neurology & Neurosurgery; Open Access Journal; juniper publishers; neurology open access journals; journal of neurology; neurology indexed journals; neurology scholarly journals; journal of neurology; neurology journals impact factor; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:joajnn:v:2:y:2017:i:5:p:92-100

DOI: 10.19080/OAJNN.2017.02.555599

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