Unfoldin, A Novel Tool for the Analysis of Protein Misfolding or Neurodegenerative Diseases

Naomi S Hachiya
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Naomi S Hachiya: Research and development Department, Tokyo metropolitan Industrial Technology Research Institute, Japan

Open Access Journal of Neurology & Neurosurgery, 2017, vol. 6, issue 3, 40-44

Abstract: The achievement of accurate protein folding in living cells is not easy. Many newly synthesized proteins fail to adopt the correct conformation, and such misfolded proteins are more likely to form aggregates. These aggregates lead to the collapse of cellular proteostasis and the formation of inclusion bodies inside or outside the cell membrane, thus exhibiting toxicity to neurons, in particular. This phenomenon has been a major causative factor of neurodegenerative diseases, including protein-misfolding/aggregation diseases.

Keywords: Open Access Journal of Neurology; Journal of Neurology & Neurosurgery; Open Access Journal; juniper publishers; neurology open access journals; journal of neurology; neurology indexed journals; neurology scholarly journals; journal of neurology; neurology journals impact factor; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:joajnn:v:6:y:2017:i:3:p:40-44

DOI: 10.19080/OAJNN.2017.06.555686

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