Toward Individualized Treatments for Neurodevelopmental Disorders Targeting Metabotropic Glutamate Receptor (mGluR) Genes Impacted by Copy Number Variants

Hain Hs, Connolly Jj, Glessner Jt, Jean Elia and Hakonarson H
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Connolly Jj: Abramson Research Center, Children’s Hospital of Philadelphia, USA
Glessner Jt: Department of Pediatrics, University of Pennsylvania, USA
Hakonarson H: Division of Human Genetics, Children’s Hospital of Philadelphia, USA

Open Access Journal of Neurology & Neurosurgery, 2018, vol. 8, issue 2, 37-42

Abstract: Development of novel therapeutics for neurodevelopmental and neuropsychiatric disorders has long been hampered by heterogeneity among phenotypes, and a lack of understanding of the molecular etiology of relevant disorders. Data from genomic studies, including copy number variants (CNVs) can give us insight into mechanisms and possible treatment targets. Studies from our group and others have identified rare disease-associated CNVs in metabotropic glutamatergic receptor (mGluR) genes in attention deficit hyperactivity disorder (ADHD), autism, and other neuropsychiatric disorders. These studies indicate that a sub-cohort of respective disease populations may be defined by genomic markers, and may respond preferentially to individualize treatment-in this case by targeting the mGluR network. We review relevant studies, including a recent clinical trial, with the objective of delineating potential next steps in translational development.

Keywords: Open Access Journal of Neurology; Journal of Neurology & Neurosurgery; Open Access Journal; juniper publishers; neurology open access journals; journal of neurology; neurology indexed journals; neurology scholarly journals; journal of neurology; neurology journals impact factor; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:joajnn:v:8:y:2018:i:2:p:37-42

DOI: 10.19080/OAJNN.2018.08.555735

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