N- and / or O- Alkylation of Quinazolinone Derivatives

Anton V Kolotaev, Vasiliy N Osipov, Karine R Matevosyan, Eugene A Bondarenko, Arthur R Mavlianberdiev and Derenik S Khachatryan
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Anton V Kolotaev: The Federal State Unitary Enterprise, Institute of Chemical Reagents and High Purity Chemical Substances of National Research Centre, Kurchatov Institute, Russia
Vasiliy N Osipov: National Research Centre, Kurchatov Institute, Russia
Karine R Matevosyan: N N Blokhin National Medical Research Center of Oncology, Russia
Derenik S Khachatryan: Mendeleev University of Chemical Technology of Russia, Russia

Organic & Medicinal Chemistry International Journal, 2020, vol. 10, issue 2, 30-37

Abstract: Here we report on a strategy based on the capabilities of 2D NMR spectroscopy, which focuses on determining the exact structures of promising HDAC / VEGF-2 inhibitors and intermediate N- or O-alkylated building blocks for their construction. Due to which, in contrast to the erroneous conclusions of other studies, it has been unequivocally established that quinazolin-4-ones with alkyl halides under the classical conditions of two-phase catalysis: the solid phase (alkali metal carbonates) and liquid (aprotic solvents) are subjected to alkylation in the 3-N- position.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:10:y:2020:i:2:p:30-37

DOI: 10.19080/OMCIJ.2020.10.555781

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