A New Approach to Design Hydroxyapatite and Silk Fibroin Bone Substitutes

Daniela Vieira, Dayane Dotto, Eliana C da S Rigo, Sheyla M C M Bicalho and Sergio A Yoshioka
Additional contact information
Daniela Vieira: Graduate Program in Bioengineering, University of São Paulo, Brazil
Eliana C da S Rigo: Experimental Surgery, Faculty of Medicine, McGill University, Canada
Sergio A Yoshioka: JHS Biomateriais, Brazil

Organic & Medicinal Chemistry International Journal, 2020, vol. 10, issue 2, 38-45

Abstract: Biomaterials to regenerate bone have been gaining great visibility in tissue engineering. The design of a material like bone is a great challenge, especially when combining the ideal mechanical strength, porosity, and bioactivity. This work focused on the development of a new candidate for bone substitute combining hydroxyapatite (HAp) and silk fibroin (SF). The silk fibroin, obtained from the cocoons of the silkworm (Bombyx mori), was dissolved using a ternary solution of calcium, ethanol, and water. HAp was co-precipitated dropping phosphate solution (Na2HPO4) in SF at a constant stirring. The final composite, 75%HAp/25%SF, were framed using a hydraulic system varying the pressure to find the best candidate. Physical and chemical characterizations were evaluated, as well as the bioactivity and cytotoxicity. Results showed excellent chemical and physical properties, like the trabecular bone. The 75%HAp/25%SF biocomposite was safe to CHO cells and presented great bioactivity being an alternative candidate to the bone regeneration field.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/omcij/pdf/OMCIJ.MS.ID.555782.pdf (application/pdf)
https://juniperpublishers.com/omcij/OMCIJ.MS.ID.555782.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:10:y:2020:i:2:p:38-45

DOI: 10.19080/OMCIJ.2020.10.555782

Access Statistics for this article

Organic & Medicinal Chemistry International Journal is currently edited by Sophia Mathis

More articles in Organic & Medicinal Chemistry International Journal from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().