Benzopyran-Core as an Antimycobacterial Agent

Sandile B Simelane, Paseka T Moshapo and Raban W Masuka
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Sandile B Simelane: Department of Chemistry, Faculty of Science and Engineering, University of Eswatini, Eswatini
Paseka T Moshapo: Department of Chemical Sciences, University of Johannesburg, South Africa
Raban W Masuka: University of Zimbabwe, School of Pharmacy, Mt Pleasant Drive, Zimbabwe

Organic & Medicinal Chemistry International Journal, 2020, vol. 10, issue 2, 56-72

Abstract: Tuberculosis (TB) is one of the world’s most deadly infectious diseases, causing 1.2 million deaths in 2018. TB is the leading cause of death from a single infectious agent, ahead of HIV/AIDS. The African continent bears the highest global TB/HIV burden and over 50% of TB cases in sub-Saharan Africa are co-infected with HIV. With an estimated 1.7 billion people (23% of the world’s population) with latent TB infection, there is an urgent need to develop drugs that will eradicate or control the disease. Moreover, the emergence of multi-drug resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB) have accelerated the need for new antitubercular agents with novel biological targets and different mechanism of action. Among the wide spectra of heterocyclic compounds, benzopyran derivatives have displayed diverse biological applications.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:10:y:2020:i:2:p:56-72

DOI: 10.19080/OMCIJ.2020.10.555784

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