In Vitro Topoisomerase II Inhibitory and Apoptotic Activities of Novel 3,5 Disubstituted Thiophene-2-carboxylates

Ananda Hanumappa, Kothanahally S. Sharath Kumar, Mahesh Hegde, H.Narasimhamurthy, Sathees C. Raghavan and Kanchugarakoppal S Rangappa
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Mahesh Hegde: Department of Studies in Chemistry, University of Mysore, India
Kanchugarakoppal S Rangappa: Department of Biochemistry, Indian Institute of Science, India

Organic & Medicinal Chemistry International Journal, 2016, vol. 1, issue 2, 47-53

Abstract: Topoisomerases (topoII) are crucial enzymes involved during DNA replication, repair and transcription. Recent studies have shown topo II as an interesting target for cancer therapy. In the current study we have synthesized and characterized few thiophene derivatives and determined their antiproliferative activity and apoptosis studies in cancer cell lines. Biochemical analysis showed that thiophene derivatives inhibit the alpha isoforms of topoisomerase II and hence these molecules can be considered as a potential anticancer drug.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:1:y:2016:i:2:p:47-53

DOI: 10.19080/OMCIJ.2016.01.555556

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