Combination Therapy Including Metformin hydrochloride for the Treatment of Diabetes and Related Comorbidity: A Patent Filed Survey

Juan Manuel Germán Acacio and David Morales-Morales
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Juan Manuel Germán Acacio: Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición SZ Universidad Nacional Autónoma de México (CIC-UNAM), México
David Morales-Morales: Instituto de Química. Universidad Nacional Autónoma de México. Circuito Exterior S/N. Ciudad Universitaria. Coyoacán. C. P. 04510. México CDMX

Organic & Medicinal Chemistry International Journal, 2017, vol. 1, issue 3, 124-159

Abstract: Diabetes is a group of metabolic dysfunctions/disorders and specifically type 2 diabetes (T2D) constitutes ~90-95% of all diabetic patients. For its treatment, Metformin hydrochloride is the most preferred anti-hyperglycemic oral agent. Due to the complexity of T2D, the use of Metformin hydrochloride alone (monotherapy) as the first-line drug has resulted to be inadequate and the addition of a second or multiple agents is necessary. Thus, in the last years there has been an enormous interest in the development of new therapeutic agents, leading to a large number of inventions (patents) regarding alternative therapies involving the use of Metformin hydrochloride in the presence of a second or more agents for the treatment and care of T2D.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:1:y:2017:i:3:p:124-159

DOI: 10.19080/OMCIJ.2017.01.555569

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