Correlation Analysis of Chitosan Physicochemical Parameters Determined by Different Methods

Tatiana Lyalina, Anastasia Zubareva, Sergey Lopatin, Vitaly Zubov, Svetlana Sizova and Elena Svirshchevskaya
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Sergey Lopatin: Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, Russia
Elena Svirshchevskaya: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Russia

Organic & Medicinal Chemistry International Journal, 2017, vol. 1, issue 3, 74-82

Abstract: Chitosan is a natural biodegradable cationic polymer with a promising potency for different applications. Its use is limited by standardization problems related to chitosan nature. The aim of this work was to compare different methods of molecular weight (MW) and deacetylation degree (DD) determination using two chitosan series varied in MW and DD. The absolute DD appeared to be accurately determined by NMR, first derivative of UV-absorbance spectra analysis, or conductometric titration. Contrary to DD, MW estimated by viscosity, size exclusion chromatography, or asymmetric field flow fractionation did not provide comparable absolute MW values. At the same time, correlation between all the methods was extremely high (Pearson’s coefficient of correlation, r~1) showing that each of them is sensitive to the change in chitosan MW. Taken collectively it can be concluded that chitosan behaves in different conditions as a molecule with different MW. As MW determined by any of these methods and viscosity correlate highly significantly, viscosity as a directly determined value is recommended to be used as the main chitosan characteristic.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:1:y:2017:i:3:p:74-82

DOI: 10.19080/OMCIJ.2017.01.555562

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