Design, Synthesis, and Biological Evaluation of Mutual Prodrugs of Some Selected NSAIDs

Nidhi Sharma, Anil Kumar Sahdev and Vinit Raj
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Nidhi Sharma: Dr. K N Modi Institute of Pharmacy & Research Centre, Modinagar, India
Vinit Raj: Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, India

Organic & Medicinal Chemistry International Journal, 2017, vol. 2, issue 3, 46-49

Abstract: Non-steroidal Anti-inflammatory drugs (Aceclofenac, Mefenamic acid) have conjugated with different antioxidants such as Thymol, Menthol which having antiulcerogenic activity with the NSAIDs- antioxidant mutual prodrug gastro sparing NSAIDs devoid of Ulcerogenic side effects. Two mutual Prodrugs have synthesized in which NSAIDs have been conjugated with different antioxidants by a glycolic acid spacer. The structure was confirmed by using IR, NMR (1H-NMR) & Characterized by some physicochemical properties including the Melting point. Titled compounds showed the significant protection towards inflammation as well as exhibited potential antibacterial activity.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:2:y:2017:i:3:p:46-49

DOI: 10.19080/OMCIJ.2017.02.555586

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