Synthesis, X-Ray diffraction, Trypanocidal activity and Molecular Studies of Benzoyl Phthalimides and Isoquinolones

Paola L Ramírez-Hernandez, Erick Suárez-Contreras, Benjamin Nogueda-Torres, Marco A. Leyva-Ramírez, Efren V García-Baez and Marco Brito-Arias
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Erick Suárez-Contreras: Unidad Profesional Interdisciplinaria de Biotecnología, IPN, México
Efren V García-Baez: Escuela Nacional de Ciencia Biológicas, Carpio y Plan de Ayala Colonia Santo Tomás, México
Marco Brito-Arias: Av.Instituto Politécnico Nacional 2508, San Pedro Zacatenco, México

Organic & Medicinal Chemistry International Journal, 2017, vol. 3, issue 2, 46-51

Abstract: α-Phthalimide acetophenones 1a-b, 3-benzoyl isoquinolones 2a-b were synthesized by following two pathways and evaluated as trypanosoal inhibitors in vitro, showing weak activity for 1a-b and 2a, and significant for 2b as compared with the reference drugs benznidazol. Also docking studies were carried out to determine the binding mode, the scoring functions and the interactions with the residues at the active site of the cruzain target enzyme.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:3:y:2017:i:2:p:46-51

DOI: 10.19080/OMCIJ.2017.03.555608

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