Design, Synthesis of Novel Thieno [2,3-d] derivatives and their Anti-Microbial studies

Virupakshi Prabhakar, Kondra Sudhakar Babu, Ravindranath Lk and Dayalan Vm
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Virupakshi Prabhakar: Faculty of Chemistry, Rgukt-Iiit Ongole, India
Ravindranath Lk: Department of Chemistry, Sri Krishnadevaraya University, India
Dayalan Vm: Faculty of Engineering Chemistry, Jawaharlal Nehru Technological University-Anantapuramu (JNTU-A), India

Organic & Medicinal Chemistry International Journal, 2017, vol. 3, issue 4, 91-102

Abstract: A new series of 4-Substituted/Heterocyclic -N-(4-(4-(trifluoromethyl/Nitro)phenoxy)thieno[2,3-d]pyrimidin-2-yl)benzamide (8 a-j) derivatives were synthesized by a five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. Several Thieno [2,3-d] Pyrimidines have been prepared from methyl 2-aminothiophene-3-carboxylate(1).The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis) from Gram positive group of bacteria. Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli) from Gram negative group of bacteria. Anti-fungal activity against Aspergillus Niger (A. Niger) and Candida albicans (C. albicans). Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugs Such as Amoxicillin & Flucanazole. From anti-bacterial and anti-fungal activity screening results, it has been observed that compounds 8j, 8i, 8h and 8g possess good activity.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:3:y:2017:i:4:p:91-102

DOI: 10.19080/OMCIJ.2017.03.555618

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