Water Pollution

Evelyn U Godwin Nwakwasi, Uchechukwu C Okoro, Mercy A Ezeokonkwo, Fidelia N Ibeanu and Ifeoma C Ugwu
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Evelyn U Godwin Nwakwasi: Department of Chemistry, Gregory University Uturu Abia State, Nigeria
Mercy A Ezeokonkwo: Department of Pure and Industrial Chemistry, University of Nigeria Nsukka, Nigeria
Fidelia N Ibeanu: School of General Studies, Natural Science Unit, University of Nigeria Nsukka, Nigeria
Ifeoma C Ugwu: Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Nigeria Nsukka, Nigeria

Organic & Medicinal Chemistry International Journal, 2018, vol. 5, issue 4, 101-106

Abstract: In a continued search for new biologically active angular phenothiazine compounds, novel non-linear polycyclic phenothiazine halogeno derivatives have been synthesized via coupling reactions. The coupling of equimolar mixture of 2-amino-5-bromopyrazine-3[4H]-thione and 6,7-dibromo-5,8-quninolinequinone under anhydrous condition, furnished two isomers, 6,9-dibromo-1, 8, 11-traiza-5H-benzo[a]phenothiazin-5-one and 6,9-dibromo-4, 8, 11-triaza-5H-benzo[a]phenothiazin-5-one. These compounds were screened for their antimicrobial activity against E. coli, Staphylococcus spp, Bacillus spp. and Pseudomonas aeruginosa at varying concentrations using Agar-well diffusion method and the results showed that these phenothiazine moieties had significant biological activity and inhibited the growth of these bacterial isolates even at low concentrations. Structures were assigned based on spectroscopic data and elemental analysis.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:5:y:2018:i:4:p:101-106

DOI: 10.19080/OMCIJ.2018.05.555666

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