Synthesis of Sildenafil Citrate Validated HPLC Method and Its Pharmaceutical Dosage Forms

Krishna Sarma Pathy and Sriraman Chakaravathy
Additional contact information
Sriraman Chakaravathy: Department of Chemistry, IPL research center Lucknow, sriramanchakravarthy, Consultant API, vadodara, india

Organic & Medicinal Chemistry International Journal, 2018, vol. 5, issue 5, 155-159

Abstract: The present study describes analytical method of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H–pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulphonyl]-4methypiperazine citrate (sildenafil Citrate). The following specification particularly describes and ascertains the nature of this invention, and the manner in which it is to be performed. Sildenafil is an oral drug used primarily to treat male sexual function problems (impotence or erectile dysfunction) since becoming available in 1998. It is a potent and selective inhibitor of cGMP specific Phosphodiesterase Type 5 (PDE5) in the corpus cavernosum, where PDE5 is responsible for degradation of cGMP. Sildenafil has a peripheral site of action on erections. This substance has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of nitric oxide on this tissue. However, there is no analytical method for determination of this active compound in pharmaceutical preparations in the current European and US Pharmacopoeia. The aim of this study was to develop and validate HPLC method for sildenafil analysis in pharmaceutical dosage forms.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
References: Add references at CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/omcij/pdf/OMCIJ.MS.ID.555674.pdf (application/pdf)
https://juniperpublishers.com/omcij/OMCIJ.MS.ID.555674.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:5:y:2018:i:5:p:155-159

DOI: 10.19080/OMCIJ.2018.05.555674

Access Statistics for this article

Organic & Medicinal Chemistry International Journal is currently edited by Sophia Mathis

More articles in Organic & Medicinal Chemistry International Journal from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().