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Preparation of Novel Morphinan Derivative as a Result of Grewe Cyclization

Sureshbabu Jayachandra, Madhuresh Kumar Sethi, Sanjay Mahajan, Bhairaiah Mara, Gurleen Kaur, Ruchira Sarbajana, Chandan Vydana, Vittal Bhattu and Purbita Chakraborty
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Purbita Chakraborty: R & D Mylan Laboratories Ltd, ANRICH Industrial Estate, India

Organic & Medicinal Chemistry International Journal, 2018, vol. 6, issue 1, 17-22

Abstract: The acid catalyzed cyclization of Benzyl substituted Octahydroisoquinoline results in the formation of a major product, N-Formyl Dextromethorphan and a minor product, one of the morphinan derivatives, which is formed via the mechanism of Super electrophiles. Excess Phosphoric acid acts as an electrophile and leads to the formation of a novel minor product but has a significant existence and can be isolated using Column Chromatography at the later stages.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:6:y:2018:i:1:p:17-22

DOI: 10.19080/OMCIJ.2018.06.555678

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