Alkylation of N,N-dimethylethanolamine with Benzhydryl Halogenide in PTC Condition

Torosyan Gh
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Torosyan Gh: National polytechnic university of Armenia, Yerevan

Organic & Medicinal Chemistry International Journal, 2018, vol. 6, issue 2, 44-45

Abstract: The direct O- alkylation of dimethylethanolamine (DMEA) by benzhydryl chloride (BhHlg) as electrophilic reagent was performed in Phase Transfer Catalysis system (PTC). It was presented the possibilities for best yield of O-alkylated product - Diphenhydramine in PTC process. The hydrochloride of obtained amino-ether is a widely known drug – dimedrol.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:6:y:2018:i:2:p:44-45

DOI: 10.19080/OMCIJ.2018.06.555684

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