Correction: Association between Technology Development and Rounder Substituted-1h-Indole-2, 3-Dione Hiv-1 Inhibitors Who Have Displays Strategic Nanomolar Cytotoxicity

Ramesh Paranjape and Rahul Hajare
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Ramesh Paranjape: National AIDS Research Institute, India
Rahul Hajare: Indian Council of Medical Research, Vinayaka Mission University, India

Organic & Medicinal Chemistry International Journal, 2018, vol. 6, issue 3, 50-53

Abstract: Model speeds drug discovery a series of novel, twenty 1,3,5-tri substituted-1H- indole 2,3-dione scaffold on a putative „U shape‟ molecular recognition of novel HIV-1 inhibitors were designed and synthesized using a parallel synthesis unit processes technology. Among synthesized and tested compounds 1A, 1B, 1C, 1D, 1E, 1F, 1G and 1H found good quality of IC50 ranges from 4.91 to 32.01μg. One among those, compound 1C is the most potent inhibitor as a target compound against HIV-1. Target compound N-[(3Z) 5-methoxy-1-(morpholin-4-ylmethyl)-2-oxo-1,2-dihydro-3H-indol-3ylidene]amino}benzene sulfamethaxazole (1C) tactically very low cytotoxicity (CC50>1mM). It is reported 7.15 μg/ml to engineered cell lines, TZM- l (JC53BL-13).

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:6:y:2018:i:3:p:50-53

DOI: 10.19080/OMCIJ.2018.06.555686

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