Synthesis of Some N-Alkyl and N-Aryl Amides as Potential Central Nervous System-Active Anticonvulsant Agents

Afolabi O Ezekiel, Agwom M Francis, Kindala T Junior and Bot J Kim
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Agwom M Francis: Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria
Bot J Kim: Department of Chemistry, Faculty of Sciences, University of Kinshasa, DR Congo

Organic & Medicinal Chemistry International Journal, 2018, vol. 6, issue 3, 60-68

Abstract: Epilepsy affects about 0.5 to 1% of the world’s population. The perfect anti-epileptic drug is as yet unavailable. A carefully balance between toxicity site of most available anti-epileptic agent and their seizure activity are mostly done before uses. New and safe anticonvulsant drugs are urgently needed. Most drugs in current usage have developed based on optimization of lead compounds, either isolated from the screening of natural products, or modified from hormone or transmitter whose activity is being studied

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:6:y:2018:i:3:p:60-68

DOI: 10.19080/OMCIJ.2018.06.555688

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