Stereoselective Synthesis of (3S, 4R)-5-Phenylpentane-1, 3, 4-Triol

R Venkateshwarlu, S Purushotham Reddy, P Venkateswara Rao and S Aravind
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S Aravind: Department of Chemistry, Osmania University, India

Organic & Medicinal Chemistry International Journal, 2018, vol. 6, issue 4, 74-76

Abstract: We describe an efficient synthesis of (3S, 4R)-5-Phenylpentane-1, 3, 4-triol (1) from commercially available 3-phenylpropanal for the first time. The key reactions involved in this synthesis are proline catalyzed hydroxylation, followed by (Z)-selective Wittig olefination, and Sharpless asymmetric epoxidation (Figure 1).

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:6:y:2018:i:4:p:74-76

DOI: 10.19080/OMCIJ.2018.06.555691

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