Quinoline-Substituted 1,2,3-Triazole-Based Molecules, As Promising Conjugated Hybrids in Biomedical Research

Luz Karime Luna Parada, Leonor Yamile Vargas Méndez and Vladimir V Kouznetsov
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Luz Karime Luna Parada: Laboratorio de Química Orgánica y Biomolecular, CMN, Universidad Industrial de Santander, Parque Tecnológico Guatiguara, Piedecuesta, Colombia
Vladimir V Kouznetsov: Grupo de Investigaciones Ambientales para el Desarrollo Sostenible, Facultad de Química Ambiental, Universidad Santo Tomás, Bucaramanga, Colombia

Organic & Medicinal Chemistry International Journal, 2018, vol. 7, issue 2, 63-72

Abstract: Building a single molecular framework containing quinoline and triazoles rings of promising biological activity through molecular hybridization strategy offers the viewpoint of better drugs for the treatment of a number of diseases including cancer, malaria, tuberculosis and other illnesses. Presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects, these molecular hybrids are gaining momentum worldwide showing their promise in drug discovery. Such hybrid molecules are usually made efficiently through click chemistry technique using multicomponent reactions. In this paper, we discuss chemistry and biology of some quinoline-substituted 1,2,3-triazole hybrids aiming at a better understanding of physicochemical properties of quinoline-triazole hybrids for designing novel bioactive chemical entities. So, principal Lipinski’ parameters and in silico study (lipophilicity and molecular polar surface area) are also briefly mentioned and applied to selected quinoline-1,2,3-triazole hybrids. The mini-review is divided in two general parts: synthetic aspects of the preparation of these hybrids and their pharmacological aspects paying attention to the widespread dangerous diseases such as malaria, cancer, and human fungal infections, especially systemic mycoses.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:7:y:2018:i:2:p:63-72

DOI: 10.19080/OMCIJ.2018.07.555708

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