Efficient Synthesis of Anti-depressant Agent Agomelatine

J Kranthi Kumar, Siva Ganesh Narala and A Venkat Narsaiah
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A Venkat Narsaiah: Department of Fluoro-Agro Chemicals, Organic Synthesis Laboratory, India

Organic & Medicinal Chemistry International Journal, 2018, vol. 7, issue 3, 103-106

Abstract: A simple and efficient synthesis of anti-depressant agent Agomelatine has been achieved in 5 steps with an overall yield 63%. The synthesis was started from commercially available starting material, ethyl-2(7-methoxynaphthalen-1-yl)-acetate (2). All the reactions are very clean and yield excellent.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:7:y:2018:i:3:p:103-106

DOI: 10.19080/OMCIJ.2018.07.555715

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