Potentiometric Determination of Asenapine Maleate Using PVC Membrane and Carbon Paste Ion-selective Electrodes

Nesrin K Ramadan, Azza A Moustafa, Taghreed A Mohamed and Rowayda M Fouad
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Azza A Moustafa: Department Analytical Chemistry, Faculty of Pharmacy, Cairo University, Egypt
Rowayda M Fouad: Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research, Egypt

Organic & Medicinal Chemistry International Journal, 2018, vol. 8, issue 1, 1-10

Abstract: Three sensitive and selective electrodes were developed for the determination of asenapine mallet. One electrode containing PVC membrane, ammomium renikate as an anion exchanger and dibutyl phthalate as a plasticizer (sensor I). Two carbon past ISE using phosphodiester acid and ammomium renikate as an anion exchanger (sensors II and III) and dibutyl phthalate as a plasticizer. The proposed electrodes showed a near-sensation response in the range from 1.00×10-5 to 1.00×10-2 mol/L for sensor I and 5.00×10-5 to 1.00×10-2 mol/L for both sensor II and III. The selectivity of the proposed electrodes to a number of interferences was investigated. Asenapine was successfully determined in pure form, pharmaceutical formulation and in presence of its oxidative degradation product.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:8:y:2018:i:1:p:1-10

DOI: 10.19080/OMCIJ.2018.08.555726

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