Synthesis of Substituted Quinazolines Containing Pharmacophoric Groups

Harutyunyan Artur A, Ghukasyan Gohar T and Danagulyan Gevorg G
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Ghukasyan Gohar T: Russian Armenian (Slavonic) University, Armenia, Europa
Danagulyan Gevorg G: Scientific and technological center of organic and pharmaceutical chemistry, Armenia

Organic & Medicinal Chemistry International Journal, 2018, vol. 8, issue 1, 15-16

Abstract: Continuing research on the synthesis of biologically active quinazoline derivatives [1,2] in this report we have described the synthesis of previously unknown substituted 2-methylquin-zolins and 2-[2-aryl(hetaryl)vinyl]quinazolines, which contain pharmacophore groups at different positions of the ring. Synthesis was carried out by the interaction of 2-methyl-4H-3,1-benzoxzin-4-ones 1a, b with aromatic and heterocyclic amines, according to the Scheme 1.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:8:y:2018:i:1:p:15-16

DOI: 10.19080/OMCIJ.2018.08.555729

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