Green Synthesis, Spectral, Thermal Characterization and Biological Activity of Schiff base Ligand Derived from 3-amino-1,2,4-triazol and its Metal Complexes

M M Abdelsalam, Ali M Hassan, Bassem H Heakal, M A Bedair, Gamal Abd El Naeem and Zaghloul I Elbialy
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M M Abdelsalam: Egyptian Organization for Standardization and Quality
Ali M Hassan: Chemistry Department, Faculty of Science, Al-Azhar University, Egypt
Bassem H Heakal: Research Laboratory, Cairo Oil Refining Company, Egypt
Zaghloul I Elbialy: The City of Scientific Research and Technology Application, New Borg El-Arab, Alexandria, Egypt

Organic & Medicinal Chemistry International Journal, 2019, vol. 8, issue 3, 49-58

Abstract: Green, efficient and clean synthesis of a Schiff base ligand, 1-(((1H-1,2,4-triazol-3-yl) imino) methyl) naphthalen-2-ol (TMN) has been synthesized in equimolar reaction (1:1) of 3-amino-1,2,4-triazole as a primary amine and 2-hydroxy-1-naphthaldehyde as an aldehyde using microwave irradiation technique. The synthesized Schiff base ligand was then reacted with four transition metal ions Co(II), Ni(II), Cu(II) and Zn(II) in 1:1 molar ratio of ligand and metal acetate using microwave technique. The stereochemistry and the bonding characteristics of the ligand and its metal complexes were achieved based on elemental analysis, FT-IR, UV-Vis., NMR and ESR as well as Thermo-Gravimetric Analysis (TGA). The thermal dehydration and decomposition of Co (II), Ni(II) and Cu(II) complexes were studied kinetically using the integral method applying the Coats-Redfern and Horowitz Metzger equations. The antimicrobial activities of ligand and its Zn (II) complex were studied against the bacterial (positive and negative) grams and fungal strains.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:8:y:2019:i:3:p:49-58

DOI: 10.19080/OMCIJ.2019.08.555736

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