NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor) Drug AZT and Their Preparation & Determination A Patent Evaluation of Efavirenz

Krishna Sarmapathy
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Krishna Sarmapathy: Department of Organic Chemistry, Head IPL research Centre, India

Organic & Medicinal Chemistry International Journal, 2019, vol. 8, issue 3, 68-77

Abstract: Human immunodeficiency virus type-1 (HIV-1) is the causative agent for the transmission and development of the acquired immunodeficiency syndrome (AIDS).Efavirenz (II) a potent NNRTI, is a significant component of a very effective (protease sparing) regimen when co administered with AZT and 3TC [1]. Importance of Efavirenz led to the development of several strategies for its synthesis, and preparation was described in this paper, the world great potential drug Efavirenz still inaccessible to millions of people because of its atom economy and toxic [2]. Patent evaluation on process patents and well defined summary of patents . During the course of drug development most of the world pharmaceutical companies attempt well in the handling of environment friendly Efavirenz development especially Merck. We have surprisingly found that compound of Efavirenz can be prepared in good yield and high purity by Cyclisation of compound of (S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol with urea. Finally, Analytical method for determination Efavirenz has the absorbance maxima at 561 nm for the first order derivative visible-Spectrophotometric method.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:8:y:2019:i:3:p:68-77

DOI: 10.19080/OMCIJ.2019.08.555739

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