Isolation and Microbial Screening of 1-Methylcyclopentene from Bracystelma Togoense Schtlr

Abiche Ekalu, Rachael Gbekele-Oluwa Ayo, James D Habila and Ibrahim Hamisu
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Abiche Ekalu: Nigerian Army School of Education, Nigeria
Ibrahim Hamisu: Ahmadu Bello University Zaria, Kaduna, Nigeria

Organic & Medicinal Chemistry International Journal, 2019, vol. 8, issue 3, 78-85

Abstract: The secondary metabolites, 1-methylcyclopentene was isolated from the CH2Cl2 extract of Brachystelma togoense used traditionally for treatment of ailments. The structure was elucidated using 1H, 13C and 2D NMR. 1-methylcyclopentene previously undescribed from plant sources had shown various biological activities S. aureus, E. coli, S. pneumonia, S. typhi, and C. albicans. It was observed that 1-methylcyclopentene was more active against C. albicans (24mm) and E. coli (20mm). 1-methylcyclopentene also showed the highest activity against E. coli (0.1875 mg/mL) and C. albicans (0.1875 mg/mL). The MBC/MFC was observed for E. coli (0.75 mg/mL), S. pneumonia (0.75 mg/mL), S. typhi (0.75 mg/mL) and C. albicans (0.375 mg/mL) respectively. The activity of 1-methylcyclopentene in B. togoense justified ethnomedicinal uses of the plant.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:8:y:2019:i:3:p:78-85

DOI: 10.19080/OMCIJ.2019.08.555740

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