Prevention of Crystallization in Stones Infection by Chemical Inhibitors

Mohamed Beghalia, Hocine Allali and Saïd Ghalem
Additional contact information
Mohamed Beghalia: Aboubakr Belkaid University, Tlemcen, Algeria
Saïd Ghalem: Laboratory of Naturals Products and Bio Actives, Lasnabio Department of Chemistry, Faculty of Sciences,

Organic & Medicinal Chemistry International Journal, 2019, vol. 8, issue 5, 102-105

Abstract: Struvite or magnesium ammonium phosphate hexahydrate (MAP) is one of the components of urinary stone. It forms in human beings as a result of urinary tract infection with urea splitting organisms. These stones can grow rapidly forming “staghorn-calculi†, which is a painful urological disorder. Therefore, it is of prime importance to study the growth and inhibition of struvite crystals. In the present work, we have exanimated the interactions between the enzyme urease and two inhibitors (aluminum and citrate acid) by molecular modeling methods. The results show that the presence of aluminum or citrate acid significantly affects struvite crystal growth. It suggested that our inhibitors induced morphology changes that reflect the interactions between the inhibitor and the crystal surfaces at a molecular level. Similar changes were observed in the presence of identical concentrations of citrate acid, and aluminum, emphasizing the unique interaction of phosphocitrate with the struvite crystal.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/omcij/pdf/OMCIJ.MS.ID.555746.pdf (application/pdf)
https://juniperpublishers.com/omcij/OMCIJ.MS.ID.555746.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:8:y:2019:i:5:p:102-105

DOI: 10.19080/OMCIJ.2019.08.555746

Access Statistics for this article

Organic & Medicinal Chemistry International Journal is currently edited by Sophia Mathis

More articles in Organic & Medicinal Chemistry International Journal from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().