Electrochemical Determination of Ascorbic Acid in Pharmaceutical Tablets using Carbon Paste Electrode

Zelalem Bitew and Meareg Amare
Additional contact information
Meareg Amare: Department of Chemistry, Bahir Dar University, Bahir Dar, Ethiopia

Organic & Medicinal Chemistry International Journal, 2019, vol. 8, issue 5, 124-132

Abstract: Cyclic voltammetry was used to study the electrochemical behavior of ascorbic acid at carbon paste electrode. Ascorbic acid showed an irreversible oxidation peak at about +470 mV. While the observed peak potential shift with pH in the range 0.5 to 6.0 indicated the participation of protons during the oxidation of ascorbic acid, the peak potential shift with scan rate in the range10–300 mV/s confirmed the irreversibility of the oxidation reaction. Under optimized method and solution parameters, an excellent linear dependence of the oxidative peak current on concentration of ascorbic acid was observed in the range 10-100 μM with limits of detection (LOD) and quantification (LOQ) of 1.76 and 5.86 μM, respectively. Detection of 93.33 to 97.58% of the expected ascorbic acid content in two local tablet formulations analyzed using the method confirmed the accuracy of the method. Recovery results in the range 91.65-91.83% for spiked standard ascorbic acid in pharmaceutical tablets further confirmed the potential applicability of the developed method for the determination of ascorbic acid in real samples.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/omcij/pdf/OMCIJ.MS.ID.555749.pdf (application/pdf)
https://juniperpublishers.com/omcij/OMCIJ.MS.ID.555749.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:8:y:2019:i:5:p:124-132

DOI: 10.19080/OMCIJ.2019.08.555749

Access Statistics for this article

Organic & Medicinal Chemistry International Journal is currently edited by Sophia Mathis

More articles in Organic & Medicinal Chemistry International Journal from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().