Treatment Efficacy of Celecoxib and Diclofenac Sodium in Rheumatoid Arthritis A Review

A N F Fasmina and R A M Rafeek
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A N F Fasmina: Department of Medical laboratory Science, Faculty of Allied Health Sciences, University of Peradeniya, Srilanka
R A M Rafeek: Department of Microbiology, Faculty of Medicine, University of Peradeniya, Srilanka

Orthopedics and Rheumatology Open Access Journals, 2018, vol. 13, issue 3, 48-54

Abstract: Administrations of drugs that reduce pain and inflammation in Rheumatoid Arthritis (RA) have resulted in the experience of adverse effects. It is important to identify most suitable drug with increased treatment efficacy and reduced adverse effects for improved quality of life. RA is an inflammatory condition that affects joints resulting in chronic pain. Due to pain and stiffness of joints, the affected have a reduced quality of life. NSAIDs are commonly administered to reduce the pain and stiffness of joints. The most commonly prescribed drugs are Celecoxib and Diclofenac Sodium which are considered in this study. This study aims to determine the suitability and effectiveness of the drugs Celecoxib and Diclofenac Na in patients having rheumatoid arthritis in terms of efficacy and tolerance. This is a systematic review for which, using Cochrane review, Google Scholar and PubMed, 5 randomized control trials were chosen. According to this study, the treatment efficacy of both the drugs was similar in reducing pain and inflammation. But it is revealed that Celecoxib had lower probability of developing GI ulcers when compared to Diclofenac Na.

Keywords: journal of orthopaedics; orthopaedics journals impact factor; orthopaedics articles impact factor; scholarly publishing orthopedics journals; juniper publishers opena ccess orthopedics journal; Rheumatology; rheumatology journals impact factor 2018; rheumatology journals impact factor; rheumatology open access journals; juniper publishers review (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:joroaj:v:13:y:2018:i:3:p:48-54

DOI: 10.19080/OROAJ.2018.13.555861

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