Intradiscal Injection of an Autologous Alpha-2-Macroglobulin (A2M) Concentrate Alleviates Back Pain in FAC-Positive Patients

Pasquale X Montesano Md, Jason M Cuellar Md and Gaetano J Scuderi MD PhD
Additional contact information
Pasquale X Montesano Md: Spine Surgeon, Montesano Spine and Sport, USA
Jason M Cuellar Md: Spine surgeon, Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, USA
Gaetano J Scuderi MD PhD: Spine surgeon, USA

Orthopedics and Rheumatology Open Access Journals, 2017, vol. 4, issue 1, 42-46

Abstract: Objectives: A cartilage degradation product, the Fibronectin-Aggrecan complex (FAC), has been identified in patients with degenerative disc disease (DDD). Alpha-2-macroglobulin (A2M) can prevent the formation of the G3 domain of aggrecan, reducing the fibronectin-aggrecan G3 complex and therefore may be an efficacious treatment. The present study was designed to determine a. The ability of autologous concentrated A2M to relieve back pain in patients with LBP from DDD and b. The ability of FAC to predict the response to this biologic therapy

Keywords: journal of orthopaedics; orthopaedics journals impact factor; orthopaedics articles impact factor; scholarly publishing orthopedics journals; juniper publishers opena ccess orthopedics journal; Rheumatology; rheumatology journals impact factor 2018; rheumatology journals impact factor; rheumatology open access journals; juniper publishers review (search for similar items in EconPapers)
Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/oroaj/pdf/OROAJ.MS.ID.555634.pdf (application/pdf)
https://juniperpublishers.com/oroaj/OROAJ.MS.ID.555634.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:joroaj:v:4:y:2017:i:1:p:42-46

DOI: 10.19080/OROAJ.2017.04.555634

Access Statistics for this article

Orthopedics and Rheumatology Open Access Journals is currently edited by Sophia Mathis

More articles in Orthopedics and Rheumatology Open Access Journals from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().