Effects of Fractionated Methanolic Leaf Extract of Gongronema latifoliumon CCl4-induced Wistar Albino Rats

Okpala Jude Chinedu, Sani Ibrahim, Nzelibe Henry Chukwuemeka and Akpa Alex Uwadiegwu
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Nzelibe Henry Chukwuemeka: Department of Biochemistry, Ahmadu Bello University, Nigeria
Akpa Alex Uwadiegwu: Department of Medical Biotechnology, National Biotechnology Development Agency, Nigeria

Journal of Pharmacology & Clinical Research, 2015, vol. 1, issue 1, 1-18

Abstract: The general aim of this study is to assess the effects of fractionated methanolic leaf extract of Gongronema latifoliumon CCl4-induced wistar albino rats. Fifty-four (54) Wistar albino rats were divided into seven treatment groups. Group A was given feed and water, Group B was injected with olive oil intra peritoneally, while the rest of the groups (C, D, E, F and G) were injected intra peritoneally with a single dose of CCl4 (148 mg/kg). After 36 hours of induction, group E, F and G were given 100 mg/kg, 150 mg/kg and 200 mg/kg body weight of n-butanol fraction of methanol leaf extract of Gongronema latifolium by oral gavage. Group D was given 100 mg/kg of silymarin (standard drug) whereas group C served as CCl4 -induced group. At the end of 28 days of treatment, there were significant (P

Keywords: Journal of Pharmacology; Pharmacology; Clinical Research; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access; open access journals; peer reviewed journals; Biochemistry & Pharmacology: Open access; Cardiovascular Pharmacology: Open Access; Clinical & Experimental Pharmacology; Journal of Molecular Biochemistry; Clinical Pharmacology & Biopharmaceutics; Forensic Toxicology & Pharmacology; juniper publishers reivew (search for similar items in EconPapers)
Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:adp:oajpcr:v:1:y:2015:i:1:p:1-18

DOI: 10.19080/JPCR.2015.01.555551

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