Clinical Evaluation of Serum Alpha Feto-Protein (AFP) and Interlukin-6 in Hepatocellular Carcinoma

S.S. Haque, Bandana Kumari, M.A. Muzaffar, Rekha Kumari, U. Kuma, A Saran, Md. Tanweeruddin and Pawan Kumar

Journal of Life Sciences Research, 2014, vol. 1, issue 1, 21-23

Abstract: Background: Hepatocellular carcinoma (HCC) is one of the important cancers worldwide and predominant in Asia and Africa. A number of evidence suggests a possible role of interleukin-6 (IL-6) and α-Fetoprotein (AFP) in the pathogenesis of hepatocellular carcinoma (HCC).Patients and methods: We studied both IL-6 and AFP in patients with HCC or in healthy controls. Serum IL-6, AFP was measured by enzyme linked immunosorbent assay and Chemiluminescent immunoassay respectively in 30 patients with primary hepatocellular carcinoma and 30 normal subjectsResults:IL-6 and AFP was found in high levels in the serum of patients initially diagnosed with HCC (18±9.8), and (315.99±594.62) respectively compared with healthy subjects (4.29±2.10).and (3.13±1.27).A significant positive correlation was found between mean levels of IL- 6 & AFP in HCC (P < 0.05), Combination of IL-6 and AFP improved the sensitivity in diagnosing HCC or predicting future HCC development. Conclusions: IL-6 along with AFP could be considered a promising tumor marker for HCC. In particular, the diagnostic value of the test is significantly increased when combined with AFP.

Keywords: AFP; HCC; IL-6. (search for similar items in EconPapers)
Date: 2014
References: Add references at CitEc
Citations:

Downloads: (external link)
http://asianonlinejournals.com/index.php/Lifsc/article/view/591/592 (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:aoj:lifscr:v:1:y:2014:i:1:p:21-23:id:591

Access Statistics for this article

More articles in Journal of Life Sciences Research from Asian Online Journal Publishing Group
Bibliographic data for series maintained by Sara Lim ().