Role of Oxidative Stress as a Novel Therapeutic Target in Myocardial Injury Due to Ischemia/Reperfusion in Patients with Acute Myocardial Infarction

Pablo Morales-Carreno () and Ramon Rodrigo ()

Journal of Life Sciences Research, 2022, vol. 9, issue 1, 1-13

Abstract: The most effective therapeutic intervention for reducing infarct size and improving outcomes in patients with acute myocardial infarction is the thrombolytic therapy or percutaneous coronary angioplasty. However, this process itself can generate ischemia-reperfusion injury that can be responsible for up to 50% of the final infarct size. Considering oxidative stress as the main damaging agent in this pathology, it has been postulated that reinforcing antioxidant defenses could improve cardiac function. However, up to date clinical trials based on monotherapies have been consistent in the favorable results. In this review the pathophysiological mechanisms of myocardial injury due to ischemia/reperfusion in patients undergoing percutaneous coronary angioplasty are updated. In addition, new therapeutic alternatives for cardioprotection in this population, are explored, with emphasis in the combined therapy as a novel antioxidant treatment for this myocardial injury.

Keywords: Oxidative stress; Antioxidants; Cardioprotection; Acute myocardial infarction; Vitamin C; Vitamin E; N-acetylcysteine; Polyphenols; Ischemia-reperfusion injury. (search for similar items in EconPapers)
Date: 2022
References: Add references at CitEc
Citations:

Downloads: (external link)
http://www.asianonlinejournals.com/index.php/Lifsc/article/view/3689/2306 (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:aoj:lifscr:v:9:y:2022:i:1:p:1-13:id:3689

Access Statistics for this article

More articles in Journal of Life Sciences Research from Asian Online Journal Publishing Group
Bibliographic data for series maintained by Sara Lim ().