Evaluation of Parasite Number and Bodyweight in Mus musculus which was Infected by Plasmodium Berghei

Istiana and Meitria Syahadatina Noor
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Istiana: Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia
Meitria Syahadatina Noor: Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia

International Journal of Health and Medical Sciences, 2018, vol. 4, issue 1, 22-27

Abstract: Malaria is infection disease because of Plasmodium Sp. and it is spread by Anopheles mosquito. Anopheles lives and breed in the field, forest, and river/beach. People who can be suffered from malaria are about 41% in the world. One of development of malaria research can be done in animal model. This research’s goal was making animal model of malaria infection with analyzing the differences of parasite number and bodyweight of Mus musculus in day 0 untill day 4 of infection. Research method was experimental using post test only with control group design and time series. Number of Mus musculus was 18/group. Infection of P. berghei was injected intraperitoneal in Mus musculus, it was called day 0. The dose was 107 of paracite in 0.2 ml of blood. Evaluation of parasite number and bodyweight of control group and infection group were done every day since day 0 until day 4. Examanation of paracite used thick and thin blood smear. Bodyweight of Mus musculus was examined by digital scale. The result was significant differences of parasite number in infected in Mus musculus among day 0, 1, 2, 3 and 4 (p = 0.031). The highest parasite numbers was in day 4 (25.44). There was significant different of bodyweight in control group (p = 0.000), an also in infection group (p = 0.000). The conclusion was P. berghei infection could be used to induce malaria infection in Mus musculus.

Keywords: Parasite number; bodyweight; P. berghei (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:apa:ijhmss:2018:p:22-27

DOI: 10.20469/ijhms.40004-1

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