Matrixmetalloproteinase-9 Genetic Variation with Cataract, Glaucoma and Retinoblastoma in a Senegalese Population

Matar Ciss, Ndéye Ndoumbé Guéye, Fatimata Mbaye*, Paul A?da Ndoye, Chérif Dial, Joseph Ndiaye and Mbacké Sembéne
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Matar Ciss: Genetic for Gestion of Population team (GENGESPOP), Department of Animal Biology, Faculty of sciences and Technics, Cheikh Anta Diop University, Dakar, Sénégal
Ndéye Ndoumbé Guéye: Ophthalmology Department, Principal Hospital, Dakar, Senegal
Fatimata Mbaye*: Genetic for Gestion of Population team (GENGESPOP), Department of Animal Biology, Faculty of sciences and Technics, Cheikh Anta Diop University, Dakar, Sénégal
Paul A?da Ndoye: Ophthalmology Department, Aristide Le Dantec Hospital, Dakar, Senegal
Chérif Dial: Anapathologic Department, Grand Yoff General Hospital, Dakar, Senegal
Joseph Ndiaye: Ophthalmology Department, Aristide Le Dantec Hospital, Dakar, Senegal
Mbacké Sembéne: Genetic for Gestion of Population team (GENGESPOP), Department of Animal Biology, Faculty of sciences and Technics, Cheikh Anta Diop University, Dakar, Sénégal

International Journal of Healthcare and Medical Sciences, 2019, vol. 5, issue 10, 52-58

Abstract: The Matrix metalloproteinase-9 is involved in several pathologies. Its strong presence in ocular pathologies explains our interest for its genetic variation in cataract, glaucoma and retinoblastoma in Senegal. MMP9 is highly polymorphic with cataract and glaucoma. 77 mutations were noted with 21 haplotypes for the entire population. The haplotype diversity Hd is 0.831 and the nucleotide diversity Pi is 0.016; k = 17.395. The polymorphism of the Matrix metalloproteinase-9 gene is associated with all three diseases and SNP 3918249 is found in both cataract and glaucoma.

Keywords: Matrix metalloproteinase-9; Cataract; Glaucoma; Polymorphism. (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:arp:ijohms:2019:p:52-58

DOI: 10.32861/ijhms.510.52.58

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