The Effects of Gene Polymorphisms in Interleukin-4 on the Susceptibility of Rheumatoid Arthritis in a Iraq Population

Ishraq Abdul Ameer Salih* and Rabab Omran
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Ishraq Abdul Ameer Salih*: Department of Biology,Science ForWomen, University of Babylon, Iraq
Rabab Omran: Department of Biology,Science , University of Babylon. Iraq

Journal of Biotechnology Research, 2018, vol. 4, issue 10, 76-79

Abstract: Rheumatoid Arthritis (RA) has been the most disease that recorded high number in Iraqi population, Interleukin-4 (IL-4) have been reported to associate with pathogenesis of rheumatoid arthritis (RA); which it is role of IL-4 genetic polymorphisms in RA. Method: A total of 50 unrelated IRAQ patients with RA and 40 healthy Iraqi volunteers with no family histories of any autoimmune diseases were recruited. The promoter IL-4-590 C/T  polymorphisms were genotyped gene polymorphism implemented used RFLP technique. Result:The results show The genotype distributions and allele frequencies of IL-4-590 C/T  polymorphisms in RA patients were significantly different from healthy Statistically significant differences were observed in genotypes for IL-4-590 .The frequencies of the T allele on the IL- 4-590 were significantly increased in RA patients. Conclusion. The IL-4-590  promoter polymorphisms may be associated with increased risk of RA and could be used as genetic marker for assessing the susceptibility and severity of RA in Iraqi.

Keywords: IL-4 gene; RFLP; Rheumatoid Arthritis. (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:arp:rjbarp:2018:p:76-79

DOI: 10.32861/jbr.410.76.79

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